Viruses & Diabetes Update

Mallol C, Casana E, Jimenez V, Casellas A, Haurigot V, Jambrina C, Sacristan V, Morró M, Agudo J, Vilà L, Bosch F. AAV-mediated pancreatic overexpression of Igf1 counteracts progression to autoimmune diabetes in mice. Mol Metab. 2017;6(7):664-680. doi: 10.1016/j.molmet.2017.05.007.

Abdel Alem S, Elsharkawy A, Fouad R, Adel E, Abdellatif Z, Musa S, Nagy A, Hussein MS, Yosry A, Esmat G. Improvement of glycemic state among responders to Sofosbuvir - based treatment regimens: Single center experience. J Med Virol. 2017 Jul 8. doi: 10.1002/jmv.24897.

Zhao G, Vatanen T, Droit L, Park A, Kostic A D, Poon T W, Vlamakis H, Siljander H, Harkonen T, Hamaleinen A, Peet A, Tillmann V, Ilonen J, Wang D, Knip M, Xavier R J, Virgin H W Intestinal virome changes precede autoimmunity in type 1 diabete-susceptible children. Proceedings of the National Academy of Science 2017 June 7 10.1073/pnas.1706359114

Dear Friends,

this week we have four contributions to our subject:

1) Overexpression of IGF1 in beta cells counteracts autoimmune diabetes in NOD mice;

2) Sofosbuvir treatment of HCV-infected diabetic subjects improves glucose homeostasis;

3) Changes in the intestinal virome appear to precede autoimmunity in diabetes-prone children. Of note, a role is being attributed to Circoviridae for the first time (instead of Picornaviridae);

4) Detection of persistent enterovirus infection in different chronic human disorders (post-polio syndrome, T1D, viral cardiomyopathy).

Have a nice week end,


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