Diabetes & Viruses - Update

Dear Friends,

This week we have four papers on our subject:-

Current Level of Evidence on Causal Association between hepatitis C virus and type 2 diabetes: a review Giacomo Gastaldia, Nicolas Goossensb, Sophie Cle ́mentc, Francesco Negrob Journal of Advanced Research, Vol 8, Issue 2, March 2017

Using spatio-temporal surveillance data to test the infectious environment of children before type 1 diabetes diagnosis PierreBougnères, SophieLeFur, Isis-Diabcollaborativegroup, SophieValtat, oichiroKamatani, MarkLathrop, Alain-JacquesValleron PLoS One. 2017 Feb 2;12(2)

Busse N, Paroni F, Richardson SJ, Laiho JE, Oikarinen M, Frisk G, Hyöty H, de Koning E, Morgan NG, Maedler K. Oncotarget. Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes. 2017 Jan 29.

Echovirus 6 Infects Human Exocrine and Endocrine Pancreatic Cells and Induces Pro-Inflammatory Innate Immune Response. Sarmiento L, Frisk G, Anagandula M, Hodik M, Barchetta I, Netanyah E, Cabrera-Rode E, Cilio CM. Viruses.2017 Jan 30;9(2). pii: E25.

Plus two papers of general interest:-

1) The enteroviral RNA-dependent RNA polymerase appears to activate the inflammasome (and the pro-inflammatory response)

2) A new method for producing NON-infectious enteroviral vaccines.

Yours, Antonio

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